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In the general chapter on microbial attributes of nonsterile pharmaceutical products, the guidance suggests that the presence of microbial contaminants in nonsterile products [25] can reduce or inactivate the therapeutic activity of the product and has the potential to adversely effect the health of the patients and recommends manufacturers to ensure that contamination levels are as low as possible for nished dosage forms. Microbial enumeration limits for raw materials (total aerobic microbial count and total combined yeasts and molds count) and nished dosage forms are described. For inhalation, nasal, and topical routes of administration, tests for total aerobic microbial count and total combined and yeast and mold count, P. aeruginosa, and S. aureus are recommended. For vaginal preparations, testing for total aerobic microbial count and total combined yeast and mold count, E. coli, S. aureus, and C. albicans is recommended, while for oral liquids and solids, testing for total aerobic microbial count and total combined and yeast and mold count and E. coli is recommended. The microbiological assessment of preservatives is required when preservatives are used in a pharmaceutical product to control microbial bioburden. The test microorganisms and methods for evaluating the ef cacy of the preservative in pharmaceutical products are described in the general chapter on preservative effectiveness tests [26].

It is likely to provide a conversion gain if properly terminated; however, it is also prone to instability if the gain is large..

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Selective Availability Originally, civilian users had their signals deliberately degraded by the US military inducing a randomly varying error, known as selective availability, ensuring that accuracy was no better than 100 metres for 95% of the time This selective availability has been switched off, but the US military may reintroduce it, without warning, at any time This must always be considered a possibility On the accompanying chart, the error that disappears northward off the chart was over 800 metres Errors that occur from a corrupt satellite signal will be incorporated into the x by a GPS receiver and can lead to very large errors, measured in miles, and will continue until the satellite is switched off by the monitoring team, which could take up to one and a half hours Differential GPS A GPS receiver xed in one place will know exactly where it is.

s , = exp(-PknA),

Any position derived from the received GPS signals can be compared with its known position and any error deduced If this error was transmitted to the nearby GPS receivers, they could take account of this error in deducing their own position to give a much more accurate result, with a 95% probability error of 3 metres This is known as differential GPS (DGPS) To take advantage of this, the GPS receiver needs both a separate DGPS receiver and to be within range of a DGPS station, usually about 200 miles This is commonly used for survey GPS and was beginning to be common for leisure users until selective availability was switched off, when its need for normal leisure use disappeared because of the inherent 15-metre accuracy Wide Area Augmentation Service Wide Area Augmentation Service (WAAS) uses a network of ground stations to monitor the GPS position accuracy.

The error corrections are sent to two master stations, which in turn send error correction information to the constellation of satellites The continuously varying error correction information is broadcast by the satellites and is then available to all WAAS compatible GPS receivers The 95% error is then reduced to 75 metres Manufacturers usually optimistically claim a 3-metre accuracy Integrity monitoring is part of this system, so anomalous.

Project risk management is a particular application of risk management. The same principles apply to project risk management as to any other application. However, projects face some specific issues relating to the way they are organized and managed and there are opportunities to develop general risk management principles into more detailed guidance. There are two professional organizations that issue guidelines on project risk management, the US-based Project Management Institute (PMI) and the UK-based Association for Project Management (APM). There are three sources of guidance on project risk management a project manager might turn to:

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